Nattokinase
Nattokinase is a digestive enzyme — an enzyme isolated from natto (fermented soybeans). 1 peer-reviewed studies are available in our database. Common forms include Nattokinase, NSK-SD.
Content reviewed by ZYNAVA Research Team · Last updated February 2026 · Editorial policy
Find Quality Nattokinase Supplements
Explore nattokinase supplements and browse options based on ingredient research.
What Is Nattokinase?
An enzyme isolated from natto (fermented soybeans).
Key fact: Labels may use FU (fibrinolytic units) to describe activity.
Nattokinase Supplement Forms
Nattokinase is available in several supplemental forms: Nattokinase, NSK-SD. Labels may use FU (fibrinolytic units) to describe activity.
Explore Nattokinase Supplements
Use our research tool to explore nattokinase supplements and see what studies have examined.
Research Studies on Nattokinase
Our database contains 1 peer-reviewed studies examining nattokinase. Below are selected recent studies:
Related Supplements
Natural Food Sources of Nattokinase
Dietary sources of nattokinase offer the advantage of providing the nutrient alongside other beneficial compounds naturally present in food. Here is a look at the most significant food sources and practical tips for optimizing your intake.
- Lean meats — Complete protein sources providing all essential amino acids
- Eggs — Considered one of the highest-quality protein sources with excellent amino acid balance
- Dairy products — Whey and casein proteins contain all essential amino acids
- Legumes — Good plant-based protein sources, though may lack some essential amino acids
- Soy products — Tofu and tempeh are complete plant proteins with all essential amino acids
Dietary Context
Amino acids are the building blocks of protein and can be obtained from a wide range of protein-rich foods. Essential amino acids must come from the diet, while the body can synthesize non-essential amino acids. Individual amino acid supplements provide concentrated doses of specific amino acids, which may be useful when dietary intake is insufficient for specific purposes.
Absorption: Food vs. Supplements
Amino acids from whole food proteins are released during digestion and absorbed in the small intestine. Free-form amino acid supplements are absorbed more rapidly since they don't require digestion. However, whole food proteins provide a complete amino acid profile along with other nutrients.
Practical Tips
- A varied diet with adequate protein from multiple sources typically provides all essential amino acids
- Combining plant proteins (grains + legumes) can provide a complete amino acid profile
- Individual amino acid supplements are best taken on an empty stomach for optimal absorption
How to Take Nattokinase
Getting the most from nattokinase supplementation involves more than just choosing the right product. When and how you take it can significantly affect absorption and effectiveness.
Best time to take: Varies by herb — check specific guidance
With or Without Food
Many herbal supplements are better tolerated when taken with food. Fat-soluble herbal compounds (like curcumin) benefit from being taken with a fat-containing meal.
How Often
Typically 1-3 times daily. Many herbs take weeks of consistent use before effects are noticeable.
Practical Tips
- Consistency is key — many herbs require weeks of regular use for noticeable effects
- Some practitioners recommend cycling herbal supplements (e.g., 8 weeks on, 2 weeks off)
- Start with lower doses and increase gradually to assess tolerance
Important Interactions
- Many herbs can interact with prescription medications — always inform your healthcare provider
- St. John's Wort is particularly known for numerous drug interactions
- Pregnant and breastfeeding women should consult a provider before using herbal supplements
This is not an exhaustive list of interactions. Always consult a healthcare provider or pharmacist about potential interactions with your specific medications and health conditions.
Where to Find Nattokinase Supplements
If you are considering nattokinase supplementation, choosing a quality product from a reputable retailer is an important step. Here are some trusted options where you can browse and compare nattokinase supplements.
How to Choose a Quality Nattokinase Supplement
- Verify the expiration date and that the product is stored appropriately
- Research the brand — established companies with transparent testing are generally more reliable
- Consider subscription options for supplements you plan to take long-term — many retailers offer discounts
- Check the other ingredients list for potential allergens (soy, gluten, dairy, nuts)
To explore supplements by ingredient or health goal, try our AI Supplement Advisor.
Important Information
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ZYNAVA maintains strict editorial independence from supplement manufacturers, retailers, and advertisers. Our research summaries are based on peer-reviewed studies indexed in databases such as PubMed, Cochrane Library, and other scientific repositories. We do not accept payment from supplement brands to feature, promote, or favorably review their products. Our evidence grading system applies consistent criteria to all supplements regardless of commercial relationships.
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